Answer
The solution for the indicated problem is $-12$.
Work Step by Step
Solve the given expression:
Recall that $-\left( -a \right)=a,c\left( -b \right)=-cb$
$\begin{align}
& 1\left( -4 \right)+2\left( 5 \right)+3\left( -6 \right)=-4+10-18 \\
& =-12
\end{align}$
Hence, the solution for the indicated problem is $-12$.
