Answer
$4x-10y$
Work Step by Step
We simplify by removing the parentheses and then add the like terms as follows:
$$
(5x + 3y) + (-3x - 3y) + (-x - 6y) + (3x - 4y)\\
=5x + 3y -3x - 3y -x - 6y + 3x - 4y\\
=4x-10y
.$$
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