Answer
$10^{17}$
Work Step by Step
$\frac{10^8\times10^{-6}\times10^{10}\times10^0}{10^4\times10^{-17}\times10^8}\longrightarrow$ to multiply powers of 10, add the exponents
$=\frac{10^{8+(-6)+10+0}}{10^{4+(-17)+8}}$
$=\frac{10^{12}}{10^{-5}}\longrightarrow$ to divide powers of 10, subtract the exponents
$=10^{12-(-5)}$
$=10^{12+5}$
$=10^{17}$