Answer
$-18\sqrt{3}-6\sqrt{5}$
Work Step by Step
Using the Distributive Property, the given expression, $
\sqrt{3}-\sqrt{5}+4\sqrt{5}-3\sqrt{3}-9\sqrt{5}-16\sqrt{3}
,$ simplifies to
\begin{array}{l}\require{cancel}
(\sqrt{3}-3\sqrt{3}-16\sqrt{3})+(-\sqrt{5}+4\sqrt{5}-9\sqrt{5})
\\\\=
(1-3-16)\sqrt{3}+(-1+4-9)\sqrt{5}
\\\\=
-18\sqrt{3}-6\sqrt{5}
.\end{array}