Answer
No. It does not make a difference which ordered pairs one uses to solve for the slope.
Work Step by Step
1. Identify the ordered pairs given
2. Choose three combinations of ordered pairs to use to solve for the slope
3. Plug these numbers into the equation for slope, and find the slope three separate times
4. Since the slopes are all equal to -.5, it can be proven that regardless of what points you use on a line to solve for the slope, the answer you get will be the same