Answer
Option A
Work Step by Step
Because the English alphabet has 26 letters, there are 26 alternatives for the first letter. Because the letters cannot be repeated, the second letter can be picked in one of 25 possible ways. There are a total of ten different digits. For the first one, there are ten possible alternatives. Because they can't be repeated, the second one can be picked in nine different ways; the third in eight; and the fourth in seven.
Hence, the number of license plates is: $26\times25\times10\times9\times8\times7=3.276.000$
Thus, the correct answer is A.