Answer
$-\frac{3y}{8x}$
Work Step by Step
Given : $\frac{\frac{1}{x} - \frac{4}{x}}{\frac{3}{y} + \frac{5}{y}}$
This becomes : $\frac{\frac{-3}{x}}{\frac{8}{y}}= - \frac{3}{x} \times \frac{y}{8}$
$-\frac{3y}{8x}$
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