Lindsay Lohan
Lindsay Lohan is an American actress who was already a well-known child star by the time she was cast in Mean Girls, having starred in Hollywood blockbusters like The Parent Trap (1998), Freaky Friday (2003), and Confessions of a Teenage Drama Queen (2003). After reading Tina Fey's script, Lohan originally wanted to play the part of super-villain Regina George, but was convinced by producers to play newcomer Cady Heron, given her star image and on-screen likability. Audiences and critics alike cheered Lohan's performance in Mean Girls, which in part led her to become the youngest ever host of the MTV Movie Awards at the age of 17.
Rachel McAdams
Rachel McAdams is a Canadian actress who starred in two breakthrough roles in 2004 that helped her become a household name—Regina George in Mean Girls, and Allison Hamilton in The Notebook. Producers cast McAdams in the role of Regina because they liked the way her natural innocence and sweetness contrasted with Regina's venomousness. She supposedly modeled her character in part on Alec Baldwin's performance in Glengarry Glen Ross (1992).
Lacey Chabert
Like Lindsay Lohan, Lacey Chabert is an American actress who began performing at a very young age, co-starring as Claudia Salinger in the FOX television show Party of Five between 1994 and 2000, which followed a family of orphaned siblings. Chabert started her career on Broadway, playing Cosette in Les Miserables. Along with Lohan, McAdams, and Amanda Seyfried, Chabert won the 2005 MTV Movie Award for Best On-Screen Team.
Amanda Seyfried
Amanda Seyfried is an American actress who began her career as a model at the age of eleven. When she was fifteen, she began acting in recurring roles on the soap operas As the World Turns and All My Children. Mean Girls was Seyfried's first major film role. Since 2004, Seyfried has become a successful and accomplished actress, starring in films like Red Riding Hood (2011), Les Miserables (2012), While We're Young (2014), and First Reformed (2017).