Lillian Hellman wrote the screenplay for a 1941 film version, a Samuel Goldwyn production directed by William Wyler. Other contributors to the screenplay included Arthur Kober, Dorothy Parker and Alan Campbell. The touring production of The Little Foxes went on hiatus for three months during filming, and Patricia Collinge, Charles Dingle, Dan Duryea, John Marriott and Carl Benton Reid all reprised their stage roles in their motion picture debuts. Bette Davis, Herbert Marshall and Teresa Wright star as Regina, Horace and Alexandra Giddens.[11]
The Little Foxes was presented on Philip Morris Playhouse October 10, 1941. The radio adaptation starred Tallulah Bankhead.[12]
In 1949, the play was adapted for an opera entitled Regina by Marc Blitzstein.
George Schaefer produced and directed Robert Hartung's television adaptation of The Little Foxes for the Hallmark Hall of Fame, broadcast December 16, 1956, on NBC. The cast included Greer Garson (Regina), Franchot Tone (Horace), Sidney Blackmer (Ben), E. G. Marshall (Oscar) and Eileen Heckart (Birdie).[13]